CHRU Brest — Direct Epidemio-Statistics Supported a Hospital-Led Trial

For the preparation of a new internally promoted project at CHRU Brest and the response to a national public health call for proposals, Direct Epidemio-Statistics carried out a critical review of the project. — We intervened as a partial RC-AVP mission.

The clinical research unit at CHRU primarily works on therapeutic interventions, and less on educational interventions, which pose challenges regarding experimental control, seasonality, and measurement.

Eight days after signature, we delivered our study including:

• Complete analysis and synthesis of measurement instruments
• Study of the trial methodology with improvement suggestions (justified)
• Ethical remarks (as methodologist)
• A series of bibliographic references

Among our proposals, the team notably accepted changing the primary endpoint, which allowed (with the same number of patients):

• 10x increase in the statistical power of the trial.

The team and the project leader summarize our contribution in three words:

A meticulous and relevant review

Mission

RC-AVP

Company

CHRU Brest

Location

Brest (29), France

Industry

Public Hospital

Web

chru-brest.fr

About:
Regional university hospital serving 1.2 million inhabitants in Western Brittany (29, 22), with approximately 2,550 beds and 6,000 hospital staff including 500 physicians.
CHRU research is organized around three INSERM units (UMR1101, UMR1078, ERI29) and five research teams.
CHRU participates in several hundred (700) research protocols involving thousands of patients.